Research · In vitro
C-phycocyanin: A biliprotein with antioxidant, anti-inflammatory and neuroprotective effects
Romay C, Armesto J, Remirez D et al. · 1998 · Current Protein and Peptide Science
Key finding
C-phycocyanin demonstrated direct free-radical scavenging activity (particularly against peroxyl and hydroxyl radicals), inhibited COX-2 and 5-LOX enzyme activity, and showed neuroprotective activity in oxidative stress models. Phycocyanin activity was dose-dependent and distinct from vitamin E.
Why this matters for consumers
The foundational mechanistic paper for phycocyanin's antioxidant and anti-inflammatory properties. Establishes the dual mechanism (direct radical scavenging + enzymatic anti-inflammatory) that is referenced across the spirulina literature. Also the earliest evidence for the neuroprotective potential.
Study limitations
In vitro study; biological activity in the test tube does not automatically translate to equivalent in vivo effect after digestion and distribution.
Related studies
Ergogenic and antioxidant effects of spirulina supplementation
Kalafati et al. · 2010
The effects of spirulina on allergic rhinitis
Cingi et al. · 2008
Anti-obesity and anti-inflammatory effects of spirulina in obese adults
Park et al. · 2008
C-phycocyanin: a biliprotein with antioxidant, anti-inflammatory and neuroprotective effects
Romay et al. · 2003
New research, when it matters
Curated science, recipes, and brand intel — once a week, no spam, unsubscribe in one click.