Research · Meta-analysis
Effects of spirulina supplementation on oxidative stress and inflammation
DiNicolantonio et al. · 2020 · Open Heart
Key finding
Meta-analysis found statistically significant reductions in malondialdehyde (oxidative stress marker) and CRP (inflammation marker), alongside significant improvements in total cholesterol, LDL, HDL, and systolic blood pressure compared to placebo.
Why this matters for consumers
A recent, well-powered meta-analysis covering oxidative stress and inflammation alongside lipid outcomes — synthesising the evidence better than single studies. The simultaneous improvements across multiple cardiovascular risk factors at the same dose suggest a coherent mechanism rather than independent effects.
Study limitations
8 studies is still a relatively small base; between-study heterogeneity in dose and duration; most studies small.
Related studies
Spirulina maxima prevents induction of fatty liver by carbon tetrachloride
Torres-Durán et al. · 2007
Antihyperlipidemic effects of spirulina in patients with type 2 diabetes
Mani et al. · 2000
Ergogenic and antioxidant effects of spirulina supplementation
Kalafati et al. · 2010
The effects of spirulina on allergic rhinitis
Cingi et al. · 2008
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